Rabu, 23 Mei 2012

One-a-day pill offers new hope on strokes: Up to 900,000 could benefit as drug gets go-ahead

One-a-day pill offers new hope on strokes: Up to 900,000 could benefit as drug gets go-ahead

By Jenny Hope

PUBLISHED: 18:04 EST, 22 May 2012 | UPDATED: 01:31 EST, 23 May 2012

The first one-a-day pill for NHS patients with an irregular heartbeat has been given the go-ahead.

Rivaroxaban works as well as warfarin, a treatment based on rat poison which has been used since the 1950s, and has fewer side-effects.

Leading doctors claim up to 900,000 patients with atrial fibrillation (AF) could be eligible for rivaroxaban, which is expected to trigger a shake-up in stroke prevention services.

An MRI of the head computer enhanced to show the normal anatomy of the brain and head suffering mini strokes. The introduction of rivaroxaban is expected to trigger a shake-up in stroke prevention services

An MRI of the head computer enhanced to show the normal anatomy of the brain and head suffering mini strokes. The introduction of rivaroxaban is expected to trigger a shake-up in stroke prevention services

It is one of a new generation of anti-clotting agents aimed at stopping strokes and other potentially fatal attacks caused by AF.

In AF the upper chambers of the heart are out of rhythm and beat much faster than normal, which allows blood to pool and generate tiny blood clots which can trigger a stroke. AF is the most common heart rhythm disturbance, affecting around 1 .2million Britons, and causes around one in seven first-time strokes.

But many sufferers remain undiagnosed and experts say extending treatment using patient-friendly drugs could prevent a further 5,000 strokes a year.

Trudie Lobban, chief executive and founder of the Atrial Fibrillation Association, said: 'Today's recommendation is welcome news for thousands who struggle with existing treatment.

'The increase in treatment choice significantly increases the likelihood patients will receive therapy that is both manageable and effective, which could have a significant impact on quality of life.'

Rivaroxaban is the second new anti-clotting agent to win approval from the NHS rationing body, the National Institute for Health and Clinical Excellence, after it recommended twice-daily Pradaxa in March.

Research shows rivaroxaban works as well as warfarin, a treatment based on rat poison which has been used since the 1950s

Research shows rivaroxaban works as well as warfarin, a treatment based on rat poison which has been used since the 1950s

AF patients have to take anti-clotting agents for life and some NHS trusts fear the new drugs will cost too much. But NICE says they are value for money, either as a replacement for warfarin or for patients who cannot take it.

Rivaroxaban costs around £64 for a month's supply whereas warfarin costs around £1 plus the cost of clinic visits, as careful monitoring and regular blood tests are needed to prevent excessive bleeding from cuts or stomach ulcers.

Warfarin, which has reduced the rate of stroke by up to two-thirds, can a lso interact badly with other drugs, alcohol and certain foods, including green vegetables and grapefruit.

A Royal College of Physicians conference estimated 5,000 strokes and 2,000 premature deaths a year could be avoided through effective detection and treatment of AF, with only half of patients currently receiving drugs.

John Camm, professor of clinical cardiology at St George's University of London, said: 'The availability of a once-daily option within the NHS that eliminates the need for routine coagulation monitoring is of significant importance for patients.'

Rivaroxaban, also known as Xarelto, works by blocking the Factor Xa protein involved in the clotting process.

The final NICE recommendation applies to England and Wales â€" Scotland has already approved the drug â€" and should be implemented by trusts within three months.

 

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Chemists dont like these once a day pill because they are going to lose a massive amount of NHS funds if their Waferine clinics are abandoned

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Well and good. But how many of these pills and tablets and capsules will a patient end up taking who already is on a cocktail of them? This is the modern trend and no one knows for certain what the consequence will be, or do we?

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Yes but it costs £2 a tablet and Pradaxa cost £1.30 a tablet and you need 2 a day until the cost comes down they will use Warfarin as its cheap,how do i know well i have AF and have had a number of strokes and TIAs but they keep trying to get me back on Warfarin which gives me bad side effects when it reacts with other medication i have to take.

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Well and good. But how many of these pills and tablets and capsules will a patient end up taking who already is on a cocktail of them? This is the modern trend and no one knows for certain what the consequence will be, or do we?

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For a natural alternative look into Nattokinase and Serrapeptase Nattokinase is an enzyme (a protein that speeds up biochemical reactions) that is extracted from a popular Japanese food called natto. Natto is boiled soybeans that have been fermented with a bacterium called Bacillus natto. Serrapeptase is an enzyme derived from silkworms.

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Yea, Fish oil and Magnesium are effective treatments for this too.

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